TGFβ and Its Role in Localized Inflammation and Immune Regulation TGFβ is critical in facilitating tissue repair during periods of localized inflammation. It generates a chemotactic gradient for T cells
Category: Articles
The Relative Absence of Tumor Necrosis Factor During the Primary Immune Response Against the VirusThe Relative Absence of Tumor Necrosis Factor During the Primary Immune Response Against the Virus
The Role of TNF in AIDS Pathophysiology In 1991, a Japanese scientific group posed the question: “Is AIDS a tumor necrosis factor (TNF) disease?” This remains a compelling inquiry with
The Initial Viral Infection and Lack of a Vigorous Pro-Inflammatory Response Against the VirusThe Initial Viral Infection and Lack of a Vigorous Pro-Inflammatory Response Against the Virus
Natural Resistance to HIV Infection It is well established that many individuals exposed to HIV never become infected. This group includes sex workers, children born to HIV-positive mothers, and individuals
Periods of Immune Control, Immune Dysfunction, Viral Propagation, and Transition to Clinical AIDSPeriods of Immune Control, Immune Dysfunction, Viral Propagation, and Transition to Clinical AIDS
The Establishment of HIV in the Body HIV becomes established in the body because the immune system is initially compromised. This immunosuppression results from a combination of physical and psychological
Background of the ScienceBackground of the Science
Natural Resistance to HIV Infection Studies show that some individuals at high risk for HIV infection remain uninfected. In some cases, genetic mutations are responsible. These mutations affect membrane receptors
AIDS Statistics and Background of the ProblemAIDS Statistics and Background of the Problem
Global HIV Infection Statistics (As of December 2001) According to the World Health Organization, by December 2001, 40 million people worldwide had been infected with HIV. This total included 37.2
Deanne’s StoryDeanne’s Story
Diagnosis of Gastrointestinal Stromal Tumor (GIST) In November 2003, during emergency surgery to address persistent vomiting, Deanne underwent resection of a 4.2 cm tumor along with 18 inches of her
The Folly of Modeling HIV Vaccine Efficacy in ChimpanzeesThe Folly of Modeling HIV Vaccine Efficacy in Chimpanzees
HIV Vaccine Research in Chimpanzees Chimpanzees are the only non-human primates in which HIV replicates. Consequently, they have been used in attempts to stimulate a vaccine response involving the production
Why Current HIV Vaccines Will FailWhy Current HIV Vaccines Will Fail
Paradox of HIV Vaccines: A Review of Envelope Immunization Despite its devastating global impact, HIV is considered by many scientists to be a remarkable example of viral complexity. Its structure
The Day AIDS Ceased to be FatalThe Day AIDS Ceased to be Fatal
Introduction In June 1994, Discover Magazine published an article titled A Deadly Masquerade by Dr. Abigail Zuger, which chronicled the case of a 26-year-old woman, Beatrice Kaye, diagnosed with advanced